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Regenerative Medicine Overview
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Stem Cells
Undifferentiated cells capable of differentiating into specialized cell types and thereby contribute to renewing and repairing tissues, offering potential for treating diseases that result from cellular loss or dysfunction.
Tissue Engineering
A practice that combines scaffolds, cells, and biologically active molecules to repair or replace damaged tissues or organs, aiming to restore normal function.
Organ Printing
A type of 3D bioprinting using cells and biomaterials to print layer-by-layer structures that mimic natural organs, potentially solving the organ shortage crisis for transplants.
Progenitor Cells
A type of stem cell that is more limited in the types of cells it can become and is partially differentiated, seen as a step between stem cells and fully differentiated cells.
Induced Pluripotent Stem Cells (iPSCs)
Adult cells that have been genetically reprogrammed to an embryonic stem cell-like state, they can differentiate into any cell type, offering a personalized approach to regenerative medicine.
Extracellular Matrix (ECM)
A complex network of proteins and carbohydrates that provide structural and biochemical support to surrounding cells, critical in tissue regeneration as it guides new tissue formation.
Biomaterials
Materials that interact with biological systems, used to create scaffolds for tissue engineering, they aim to mimic the natural cellular environment and promote tissue growth.
Cellular Therapeutics
Treatments based on the transplantation of whole cells into a patient to restore the function of damaged tissues or organs, potentially offering cures for a variety of diseases.
Gene Therapy
The therapeutic delivery of nucleic acid into a patient's cells as a drug to treat disease, it aims to correct or compensate for mutant genes or enhance a biological function.
Growth Factors
Naturally occurring proteins capable of stimulating cellular growth, proliferation, and cellular differentiation, key agents in tissue repair and regeneration processes.
Biomimicry
The design and production of materials, structures, and systems that are modeled on biological entities and processes, aimed to improve regenerative medicine approaches by mimicking nature.
Decellularization
A process whereby cellular material is removed from donor tissues to leave behind an ECM scaffold, which can then be recellularized with a patient's own cells to avoid rejection.
Recellularization
The introduction of cells into a decellularized ECM to produce functional tissues or organs, with the aim to create patient-specific implants that reduce the risk of immune rejection.
Angiogenesis
The development of new blood vessels from pre-existing ones, an important aspect of tissue regeneration to ensure that engineered tissues receive sufficient nutrients and oxygen.
Somatic Cell Nuclear Transfer (SCNT)
A laboratory strategy to create a viable embryo from a body cell and an egg cell, used in the context of regenerative medicine to create patient-specific embryonic stem cells.
Smart Biomaterials
Biomaterials designed to respond to biological signals and trigger appropriate therapeutic responses, enhancing the body’s natural regenerative capacity.
Cell Homing
The process by which cells migrate to the site of injury and contribute to tissue repair, a mechanism leveraged in regenerative medicine to enhance healing and organ regeneration.
Microenvironment Manipulation
Altering the local cellular and extracellular environment to promote tissue growth and healing, involves modifying factors like pH, oxygen levels, and growth factor delivery.
Direct Reprogramming
A technique to convert one type of mature cell directly into another without going through a pluripotent stage, offering potential for generating tissue-specific cells for therapy.
Autologous Cell Therapy
The use of an individual's own cells for treatment, minimizing the risk of immune rejection and complications associated with allogeneic transplants.
Allogeneic Cell Therapy
The transplantation of donor cells into a recipient for therapeutic purposes, with considerations for immune compatibility and potential for off-the-shelf treatments.
Xenogeneic Cell Therapy
The use of cells from one species transplanted into another species, requiring extensive research to overcome immune barriers, currently a prospective avenue in regenerative medicine.
Cryopreservation of Cells
The process of cooling and storing cells at very low temperatures to preserve their integrity for future use in regenerative therapies.
Biofabrication
The automated production of complex biological products such as tissues and organs, utilizing techniques like 3D printing and self-assembling materials to create functional structures.
Immunomodulation in Regeneration
Modifying the immune response to promote tissue repair and regeneration, potentially decreasing inflammation and enabling constructive tissue remodeling.
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