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Physiology: Cardiovascular System

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Heart

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Pumps blood throughout the body, maintains blood pressure and ensures oxygen and nutrients are delivered to tissues.

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Aorta

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The largest artery in the body, it distributes oxygenated blood to all parts of the body via the systemic circulation.

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Arteries

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Carry oxygenated blood away from the heart to the body's tissues, have thick walls to withstand high pressure.

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Chordae Tendineae

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Heart strings that anchor the valves (tricuspid and mitral) to the muscles of the heart to prevent them from inverting.

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Veins

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Carry deoxygenated blood back to the heart, have valves to prevent backflow and thinner walls than arteries.

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White Blood Cells (Leukocytes)

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Part of the immune system, help defend the body against infection and remove waste, dead, or damaged cells.

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Sinus Node (SA Node)

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The natural pacemaker of the heart, it initiates each heartbeat and sets the pace for the whole heart.

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Heart Valves

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Ensure one-way blood flow through the heart's four chambers—tricuspid, pulmonic, mitral, and aortic.

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Pericardium

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A double-walled sac containing the heart and the roots of the great vessels, providing protection and anchoring the heart within the thorax.

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Lymphatic Vessels

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Transport excess interstitial fluid (lymph) from tissues and return it to the bloodstream.

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Pulmonary Arteries

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Carry deoxygenated blood from the right ventricle to the lungs.

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Pulmonary Circulation

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The pathway of blood flow between the heart and lungs for the exchange of oxygen and carbon dioxide.

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Endocardium

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The thin inner lining of the heart’s chambers; it's continuous with the inner lining of blood vessels and decreases friction between the blood and the heart wall.

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Diastole

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The phase of the cardiac cycle when the heart muscle relaxes and the chambers fill with blood.

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Capillaries

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Microscopic blood vessels where the exchange of oxygen, nutrients, and waste products occurs between blood and tissues.

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Vena Cava

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Largest veins in the body, include the superior vena cava (drains the upper body) and the inferior vena cava (drains the lower body), delivering deoxygenated blood back to the heart.

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Pulmonary Veins

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Carry oxygenated blood from the lungs to the left atrium of the heart.

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Systole

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The phase of the cardiac cycle during which the ventricles contract and pump blood out of the heart.

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Red Blood Cells (Erythrocytes)

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Transport oxygen from the lungs to the body's tissues using hemoglobin and remove carbon dioxide from tissues.

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Platelets (Thrombocytes)

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Small cell fragments involved in clot formation to prevent bleeding.

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Coronary Arteries

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Supply oxygen-rich blood to the heart muscle itself.

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Plasma

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Liquid component of blood, a mixture of water, proteins, electrolytes, nutrients, and waste products.

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Atrioventricular Node (AV Node)

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Acts as an electrical relay station, slowing the electrical current sent by the SA node before the signal is passed to the ventricles.

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Cardiac Output

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The volume of blood being pumped by the heart, in particular by a left or right ventricle, in one minute. Calculated as CO=HR×SVCO = HR \times SV, where CO is cardiac output, HR is heart rate, and SV is stroke volume.

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Systemic Circulation

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The part of the cardiovascular system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart.

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His-Purkinje System

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Transmits electrical impulses from the AV node throughout the ventricles, allowing for a coordinated contraction.

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Papillary Muscles

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Located in the ventricles of the heart, they contract to tighten the chordae tendineae and prevent the inversion of the valves during systole (ventricular contraction).

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Myocardium

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The middle muscular layer of the heart wall, responsible for the pumping action.

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Blood Pressure

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The force that circulating blood exerts against the wall of the body's arteries, expressed by two measurements: systolic (during heart contraction) over diastolic (during heart relaxation).

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Baroreceptors

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Sensory receptors that detect changes in blood pressure and relay information to the brainstem to adjust heart rate and blood vessel diameter.

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Cardiac Cycle

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The sequence of mechanical and electrical events that repeats with every heartbeat. It includes diastole, atrial systole, isovolumetric contraction, ventricular ejection, and isovolumetric relaxation.

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Vagus Nerve

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Helps regulate the heart rate via parasympathetic innervation, often leading to a decrease in heart rate.

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Stroke Volume

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The amount of blood pumped out of the ventricle with each contraction, can be calculated using the formula SV=EDVESVSV = EDV - ESV, where SV is stroke volume, EDV is end-diastolic volume, and ESV is end-systolic volume.

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Afterload

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The resistance against which the heart must pump to eject blood during systole, often equated with arterial blood pressure.

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Ejection Fraction

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The percentage of blood that is ejected out of the ventricles with each heart beat, a common measure of heart efficiency. Calculated as EF=SVEDV×100EF = \frac{SV}{EDV} \times 100, where EF is ejection fraction, SV is stroke volume, and EDV is end-diastolic volume.

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Frank-Starling Law of the Heart

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The relationship between stroke volume and preload, stating that the greater the volume of blood in the heart before contraction, the greater the volume of blood ejected during systole.

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Hemoglobin

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A protein in red blood cells that carries oxygen from the lungs to the tissues of the body and returns carbon dioxide from the tissues back to the lungs.

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Preload

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The degree of stretch of the cardiac muscle fibers at the end of diastole, just before contraction, influenced by the venous return and volume of blood in the ventricles.

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