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Histology of the Gastrointestinal Tract

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Enterocytes

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Enterocytes are absorptive columnar epithelial cells that absorb nutrients; located in the lining of the small intestine.

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Interstitial cells of Cajal

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The interstitial cells of Cajal act as pacemakers for smooth muscle cells, coordinating peristalsis; found in the muscularis externa of the GI tract.

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Myenteric plexus

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The myenteric plexus controls GI tract motility by coordinating muscle contractions; it's located between the layers of the muscularis externa.

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Muscularis Externa

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The muscularis externa consists of smooth muscle layers responsible for peristalsis and segmentation; it's located surrounding the submucosa along the entire GI tract.

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Paneth cells

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Paneth cells secrete antibacterial enzymes like lysozyme, contributing to gut immunity; located at the base of intestinal crypts in the small intestine.

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Mucosa

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The mucosa is the innermost layer of the GI tract that contains glands, epithelium, and lamina propria; it functions in secretion and absorption and can be found throughout the GI tract.

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Serosa

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Serosa is the outermost protective layer of the GI tract that secretes serous fluid to reduce friction; found in the intraperitoneal parts of the GI tract.

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Parietal cells

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Parietal cells produce hydrochloric acid and intrinsic factor, essential for digestion and B12 absorption; they are located in the stomach lining.

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Goblet cells

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Goblet cells are mucus-secreting cells that lubricate and protect the GI tract lining; found interspersed among enterocytes in the intestines.

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Enteroendocrine cells

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Enteroendocrine cells secrete hormones that regulate digestion and metabolism; scattered throughout the gastrointestinal epithelium.

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Kupffer cells

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Kupffer cells are liver macrophages that destroy pathogens and remove debris; located in the liver sinusoids.

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M cells

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M cells are specialized cells for antigen sampling and transport in the immune system, found in the lymphoid follicles of the ileum in the small intestine.

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Brush border cells

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Brush border cells have microvilli that increase surface area for nutrient absorption, located in the lining of the small intestine.

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Submucosa

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Submucosa is a layer of connective tissue containing blood vessels, nerves, and glands that supports the mucosa and assists in the GI tract's vascular function; it is found surrounding the mucosa throughout the GI tract.

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Chief cells

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Chief cells synthesize and secrete digestive enzymes, such as pepsinogen; present in the stomach's gastric pits.

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