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Normal Bone Physiology
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Osteoclasts
Involved in bone resorption, breaking down bone tissue, which is crucial for growth, healing, and remodeling.
Osteocytes
Mature bone cells that maintain the bone matrix and transmit mechanical strains through the bone.
Hydroxyapatite
Provides hardness and strength to bones, allowing them to withstand compression.
Spongy Bone
Reduces the density of bone, making it lighter and providing space for marrow and blood vessels.
Osteoblasts
Responsible for bone formation, secretes bone matrix and initiates calcification.
Periosteum
Protects bone and serves as an attachment site for muscles and ligaments, also involved in bone growth and repair.
Calcium Homeostasis
Regulates the bone remodeling process, influenced by calcium intake, vitamin D levels, and hormones like parathyroid hormone.
Bone Marrow
Produces blood cells and platelets, important for immunity and clotting.
Wolff's Law
Bone in a healthy person or animal will adapt to the loads under which it is placed.
Canaliculi
Allow for communication between osteocytes and the exchange of nutrients and waste products.
Collagen Fibers
Contributes to the flexibility and tensile strength of bones, reducing the risk of fractures.
Parathyroid Hormone (PTH)
Increases blood calcium levels by stimulating osteoclast activity, thus regulating bone resorption.
Compact Bone
Provides strength and rigidity to bones, acts as a supportive structure.
Volkmann's Canals
Allow for vascular and nerve supply to deeper bone tissues and communication with the bone's exterior.
Bone Mineral Density (BMD)
Reflects the strength of bones and their resistance to fracture.
Growth Plates (Epiphyseal Plates)
Responsible for longitudinal bone growth during childhood and adolescence.
Endosteum
Lines the inner surface of bone cavities, involved in bone growth, repair, and remodeling.
Vitamin D
Facilitates calcium absorption in the gut, essential for normal bone formation and remodeling.
Haversian Systems (or Osteons)
Structural unit of compact bone, allows for nutrient and waste exchange.
Lamellae
Thin layers of bone tissue in compact bone that add strength and stability.
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