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Normal Bone Physiology

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Osteoclasts

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Involved in bone resorption, breaking down bone tissue, which is crucial for growth, healing, and remodeling.

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Osteocytes

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Mature bone cells that maintain the bone matrix and transmit mechanical strains through the bone.

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Hydroxyapatite

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Provides hardness and strength to bones, allowing them to withstand compression.

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Spongy Bone

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Reduces the density of bone, making it lighter and providing space for marrow and blood vessels.

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Osteoblasts

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Responsible for bone formation, secretes bone matrix and initiates calcification.

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Periosteum

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Protects bone and serves as an attachment site for muscles and ligaments, also involved in bone growth and repair.

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Calcium Homeostasis

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Regulates the bone remodeling process, influenced by calcium intake, vitamin D levels, and hormones like parathyroid hormone.

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Bone Marrow

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Produces blood cells and platelets, important for immunity and clotting.

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Wolff's Law

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Bone in a healthy person or animal will adapt to the loads under which it is placed.

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Canaliculi

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Allow for communication between osteocytes and the exchange of nutrients and waste products.

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Collagen Fibers

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Contributes to the flexibility and tensile strength of bones, reducing the risk of fractures.

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Parathyroid Hormone (PTH)

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Increases blood calcium levels by stimulating osteoclast activity, thus regulating bone resorption.

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Compact Bone

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Provides strength and rigidity to bones, acts as a supportive structure.

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Volkmann's Canals

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Allow for vascular and nerve supply to deeper bone tissues and communication with the bone's exterior.

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Bone Mineral Density (BMD)

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Reflects the strength of bones and their resistance to fracture.

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Growth Plates (Epiphyseal Plates)

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Responsible for longitudinal bone growth during childhood and adolescence.

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Endosteum

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Lines the inner surface of bone cavities, involved in bone growth, repair, and remodeling.

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Vitamin D

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Facilitates calcium absorption in the gut, essential for normal bone formation and remodeling.

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Haversian Systems (or Osteons)

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Structural unit of compact bone, allows for nutrient and waste exchange.

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Lamellae

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Thin layers of bone tissue in compact bone that add strength and stability.

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