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Pathology of Bone Tumors

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Osteosarcoma

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Characteristics: Malignant, osteoid-producing tumor. Typical location: Long bones (distal femur, proximal tibia). Potential treatments: Surgery, chemotherapy, and possible limb-sparing procedures.

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Metastatic Bone Disease

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Characteristics: Secondary bone tumors from other primary cancers. Typical location: Spine, pelvis, ribs, and long bones. Potential treatments: Depends on primary cancer; may include chemotherapy, radiation therapy, and surgery.

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Simple Bone Cyst

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Characteristics: Benign fluid-filled cavity. Typical location: Proximal humerus and femur. Potential treatments: Observation, aspiration, and injection with steroids or bone marrow, surgical curettage with bone grafting.

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Aneurysmal Bone Cyst

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Characteristics: Expansive and blood-filled bone lesion. Typical location: Metaphysis of long bones and vertebrae. Potential treatments: Curettage with bone grafting, embolization, and possible excision for recurrent cases.

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Osteoblastoma

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Characteristics: Benign bone lesion larger than osteoid osteoma. Typical location: Spine and long bones. Potential treatments: Surgical excision, curettage with bone grafting.

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Osteochondroma

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Characteristics: Benign bone tumor with a cartilage cap. Typical location: Metaphysis of long bones, such as the femur and tibia. Potential treatments: Observation, surgical excision if symptomatic or for suspected malignancy transformation.

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Enchondroma

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Characteristics: Benign cartilage tumor within the medullary bone. Typical location: Small bones of the hands and feet, long bone diaphysis. Potential treatments: Observation, surgical curettage and bone grafting if symptomatic or for suspected malignancy.

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Chondrosarcoma

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Characteristics: Malignant cartilage-forming tumor. Typical location: Pelvis, femur, and shoulder. Potential treatments: Surgical resection, sometimes with adjuvant chemotherapy or radiation.

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Multiple Myeloma

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Characteristics: Malignant plasma cell disorder affecting bone marrow. Typical location: Vertebral bodies, ribs, skull, pelvis, and femur. Potential treatments: Chemotherapy, stem cell transplant, radiation therapy, and supportive care.

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Fibrous Dysplasia

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Characteristics: Benign, fibrous bone lesion replacing normal marrow. Typical location: Femur, tibia, ribs, and skull. Potential treatments: Observation, surgical curettage and bone grafting, bisphosphonates to decrease pain.

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Adamantinoma

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Characteristics: Low-grade malignant tumor, epithelial origin. Typical location: Tibia primarily, sometimes the fibula. Potential treatments: Wide surgical resection, occasionally amputation for extensive disease.

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Ewing Sarcoma

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Characteristics: Highly malignant tumor with small round cells. Typical location: Pelvic bones, femur, and chest wall. Potential treatments: Multiagent chemotherapy, surgery, and radiation therapy.

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Osteoid Osteoma

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Characteristics: Benign, small, and painful tumor. Typical location: Cortex of long bones, particularly the femur and tibia. Potential treatments: Nonsteroidal anti-inflammatory drugs (NSAIDs), radiofrequency ablation, or surgical excision.

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Giant Cell Tumor of Bone

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Characteristics: Generally benign but can be locally aggressive. Typical location: Epiphyses of long bones, especially around the knee. Potential treatments: Curettage with bone grafting or cement, wide resection in recurrent cases.

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Chordoma

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Characteristics: Malignant tumor of notochordal origin. Typical location: Sacrum and base of the skull (clivus). Potential treatments: Wide surgical resection, postoperative radiotherapy, new targeted therapies under investigation.

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