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Child and Adolescent Psychopharmacology

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Methylphenidate

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Primary pediatric indication: ADHD; Dosing concerns: Adjust doses based on weight and response.

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Atomoxetine

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Primary pediatric indication: ADHD; Dosing concerns: Hepatic impairment requires dosage adjustment.

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Fluoxetine

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Primary pediatric indication: Major Depressive Disorder & OCD; Dosing concerns: Start with lower doses due to risk of increased suicidal ideation.

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Sertraline

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Primary pediatric indication: OCD; Dosing concerns: Monitor for weight loss and growth inhibition in pediatric patients.

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Risperidone

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Primary pediatric indication: Autistic disorder irritability; Dosing concerns: Risk of weight gain and metabolic syndrome, start low, go slow.

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Aripiprazole

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Primary pediatric indication: Autistic disorder irritability, bipolar I, schizophrenia; Dosing concerns: Weight, metabolic monitoring, and dose adjustments for CYP2D6 inhibitors.

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Guanfacine

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Primary pediatric indication: ADHD; Dosing concerns: Dose needs to be tapered to discontinue to avoid rebound hypertension.

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Clonidine

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Primary pediatric indication: ADHD; Dosing concerns: Caution with dosing due to potential for hypotension and bradycardia.

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Lisdexamfetamine

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Primary pediatric indication: ADHD; Dosing concerns: Prodrug, dose based on weight and conversion to active form.

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Amphetamine/Dextroamphetamine

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Primary pediatric indication: ADHD; Dosing concerns: Consider cardiovascular risks and potential for abuse.

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Divalproex Sodium

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Primary pediatric indication: Bipolar disorder, seizures; Dosing concerns: Hepatic function monitoring and potential teratogenic effects.

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Lamotrigine

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Primary pediatric indication: Bipolar disorder, seizures; Dosing concerns: Need to titrate slowly to minimize the risk of rash.

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Lithium

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Primary pediatric indication: Bipolar disorder; Dosing concerns: Narrow therapeutic index, requires blood level monitoring.

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Escitalopram

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Primary pediatric indication: Major Depressive Disorder & generalized anxiety disorder; Dosing concerns: Consider dose adjustment in hepatic and renal impairment.

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Ritalin LA

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Primary pediatric indication: ADHD; Dosing concerns: Extended-release formulation allows for once-daily dosing, monitor for insomnia.

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Concerta

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Primary pediatric indication: ADHD; Dosing concerns: Extended-release formulation provides all-day symptom control, monitor for weight loss.

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Adderall XR

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Primary pediatric indication: ADHD; Dosing concerns: Extended-release amphetamine blend, monitor for drug dependence.

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Quetiapine

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Primary pediatric indication: Bipolar disorder, schizophrenia; Dosing concerns: Monitor for metabolic syndrome and adjust dose in hepatic impairment.

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Ziprasidone

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Primary pediatric indication: Bipolar disorder, schizophrenia; Dosing concerns: Take with food to improve absorption, monitor ECG for QT prolongation.

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Olanzapine

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Primary pediatric indication: Bipolar disorder, schizophrenia; Dosing concerns: Significant risk for weight gain and metabolic effects, monitor blood glucose and lipids.

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