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Child and Adolescent Psychopharmacology
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Methylphenidate
Primary pediatric indication: ADHD; Dosing concerns: Adjust doses based on weight and response.
Atomoxetine
Primary pediatric indication: ADHD; Dosing concerns: Hepatic impairment requires dosage adjustment.
Fluoxetine
Primary pediatric indication: Major Depressive Disorder & OCD; Dosing concerns: Start with lower doses due to risk of increased suicidal ideation.
Sertraline
Primary pediatric indication: OCD; Dosing concerns: Monitor for weight loss and growth inhibition in pediatric patients.
Risperidone
Primary pediatric indication: Autistic disorder irritability; Dosing concerns: Risk of weight gain and metabolic syndrome, start low, go slow.
Aripiprazole
Primary pediatric indication: Autistic disorder irritability, bipolar I, schizophrenia; Dosing concerns: Weight, metabolic monitoring, and dose adjustments for CYP2D6 inhibitors.
Guanfacine
Primary pediatric indication: ADHD; Dosing concerns: Dose needs to be tapered to discontinue to avoid rebound hypertension.
Clonidine
Primary pediatric indication: ADHD; Dosing concerns: Caution with dosing due to potential for hypotension and bradycardia.
Lisdexamfetamine
Primary pediatric indication: ADHD; Dosing concerns: Prodrug, dose based on weight and conversion to active form.
Amphetamine/Dextroamphetamine
Primary pediatric indication: ADHD; Dosing concerns: Consider cardiovascular risks and potential for abuse.
Divalproex Sodium
Primary pediatric indication: Bipolar disorder, seizures; Dosing concerns: Hepatic function monitoring and potential teratogenic effects.
Lamotrigine
Primary pediatric indication: Bipolar disorder, seizures; Dosing concerns: Need to titrate slowly to minimize the risk of rash.
Lithium
Primary pediatric indication: Bipolar disorder; Dosing concerns: Narrow therapeutic index, requires blood level monitoring.
Escitalopram
Primary pediatric indication: Major Depressive Disorder & generalized anxiety disorder; Dosing concerns: Consider dose adjustment in hepatic and renal impairment.
Ritalin LA
Primary pediatric indication: ADHD; Dosing concerns: Extended-release formulation allows for once-daily dosing, monitor for insomnia.
Concerta
Primary pediatric indication: ADHD; Dosing concerns: Extended-release formulation provides all-day symptom control, monitor for weight loss.
Adderall XR
Primary pediatric indication: ADHD; Dosing concerns: Extended-release amphetamine blend, monitor for drug dependence.
Quetiapine
Primary pediatric indication: Bipolar disorder, schizophrenia; Dosing concerns: Monitor for metabolic syndrome and adjust dose in hepatic impairment.
Ziprasidone
Primary pediatric indication: Bipolar disorder, schizophrenia; Dosing concerns: Take with food to improve absorption, monitor ECG for QT prolongation.
Olanzapine
Primary pediatric indication: Bipolar disorder, schizophrenia; Dosing concerns: Significant risk for weight gain and metabolic effects, monitor blood glucose and lipids.
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