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Pharmacological Management of PTSD

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Sertraline

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Use in PTSD: Sertraline is an SSRI used to treat PTSD. Common side effects: Insomnia, gastrointestinal issues, and sexual dysfunction.

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Paroxetine

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Use in PTSD: Paroxetine is an SSRI approved for the treatment of PTSD. Common side effects: Weight gain, drowsiness, and sexual dysfunction.

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Fluoxetine

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Use in PTSD: Fluoxetine is an SSRI that may be used off-label for PTSD. Common side effects: Nausea, nervousness, and insomnia.

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Venlafaxine

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Use in PTSD: Venlafaxine is an SNRI that may be used off-label for PTSD. Common side effects: Increased blood pressure, dizziness, and sleep disturbances.

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Prazosin

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Use in PTSD: Prazosin is used off-label to treat nightmares related to PTSD. Common side effects: Dizziness, headache, and drowsiness.

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Mirtazapine

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Use in PTSD: Mirtazapine is used off-label to help alleviate symptoms of PTSD. Common side effects: Appetite increase, weight gain, and sedation.

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Propranolol

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Use in PTSD: Propranolol is used off-label to help with physical symptoms of PTSD and may help with reconsolidation of traumatic memories. Common side effects: Fatigue, dizziness, and hypotension.

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Amitriptyline

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Use in PTSD: Amitriptyline is a tricyclic antidepressant, sometimes used off-label for PTSD. Common side effects: Dry mouth, constipation, and blurred vision.

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Quetiapine

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Use in PTSD: Quetiapine is an atypical antipsychotic that can be used off-label for PTSD, particularly for sleep problems. Common side effects: Sedation, weight gain, and metabolic changes.

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Risperidone

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Use in PTSD: Risperidone, an atypical antipsychotic, is used off-label in cases of severe PTSD symptoms. Common side effects: Weight gain, metabolic syndrome, and extrapyramidal symptoms.

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Lamotrigine

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Use in PTSD: Lamotrigine is an anticonvulsant used off-label for PTSD to help control symptoms like mood swings. Common side effects: Skin rash, dizziness, and blurred vision.

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Topiramate

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Use in PTSD: Topiramate is an anticonvulsant used off-label to potentially alleviate PTSD symptoms. Common side effects: Weight loss, cognitive issues, and tingling in hands or feet.

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