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Partial agonist at D2 receptors, effective for positive and some negative symptoms. Side effects include headache, anxiety, insomnia, and risk of extrapyramidal symptoms (EPS).

Effective for treatment-resistant schizophrenia for both positive and negative symptoms. Side effects include agranulocytosis, weight gain, sedation, and anticholinergic effects.

Effective for positive and negative symptoms. Side effects include significant weight gain, metabolic syndrome, sedation, and anticholinergic effects.

Effective for positive symptoms and some negative symptoms. Side effects include EPS, hyperprolactinemia, weight gain, and metabolic changes.

Effective for positive symptoms; efficacy for negative symptoms is less established. Side effects include sedation, orthostatic hypotension, and weight gain.

Highly effective for positive symptoms but limited efficacy for negative symptoms. Side effects include high risk of EPS, tardive dyskinesia, and anticholinergic effects.

Effective for positive and negative symptoms; has a favorable side effect profile with less weight gain. Side effects include akathisia, sedation, and nausea.

Effective for positive and negative symptoms; lower risk of weight gain. Side effects include QT prolongation, sedation, and EPS at higher doses.

Selective for D2/D3 receptors, effective for positive and negative symptoms. Side effects include increased prolactin levels, EPS, and insomnia.

Effective for both positive and negative symptoms. Side effects include EPS, tachycardia, weight gain, and increased prolactin levels.

Efficacy for positive and mixed results for negative symptoms. Side effects include oral hypoesthesia, weight gain, and EPS.

Efficacy for positive symptoms, and lesser data on negative symptoms. Side effects include weight gain, dizziness, fatigue, and nasal congestion.

Effective for positive and negative symptoms, acts as a D2 and D3 partial agonist. Side effects include EPS, akathisia, and gastrointestinal symptoms.

Effective for positive symptoms and may have benefits for negative symptoms. Side effects include weight gain, nasopharyngitis, and EPS.

Effective for positive symptoms, with questionable effects on negative symptoms. Side effects include EPS, especially at higher doses, weight gain, and anticholinergic effects.

Effective for positive symptoms, less so for negative symptoms. Side effects include sedation, hypotension, weight gain, and considerable anticholinergic effects.

Effective for positive symptoms, and less data on negative symptoms. Side effects include QT prolongation, sedation, weight gain, and anticholinergic effects.

Effective for positive and negative symptoms. Side effects include drowsiness, increased appetite, EPS, and anticholinergic effects.

Effective for positive symptoms, unclear benefits for negative symptoms. Side effects include high risk of EPS, and also weight gain, and hypotension.