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Opioid Analgesics and Antagonists
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Morphine
Use: Severe pain treatment, Addiction potential: High, Overdose treatment: Naloxone
Fentanyl
Use: Severe pain, surgical analgesia, Addiction potential: Very High, Overdose treatment: Naloxone
Codeine
Use: Mild to moderate pain, cough suppression, Addiction potential: Moderate, Overdose treatment: Naloxone
Oxycodone
Use: Moderate to severe pain, Addiction potential: High, Overdose treatment: Naloxone
Hydrocodone
Use: Moderate to severe pain, Addiction potential: High, Overdose treatment: Naloxone
Methadone
Use: Chronic pain, opioid addiction treatment, Addiction potential: High, Overdose treatment: Naloxone
Buprenorphine
Use: Opioid addiction treatment, chronic pain, Addiction potential: Moderate, Overdose treatment: Naloxone
Heroin
Use: Not medically used in the US, Addiction potential: Very High, Overdose treatment: Naloxone
Naloxone
Use: Opioid overdose treatment, Addiction potential: None, Overdose treatment: Not applicable
Naltrexone
Use: Alcohol and opioid addiction treatment, Addiction potential: None, Overdose treatment: Not applicable
Tramadol
Use: Moderate pain, Addiction potential: Moderate, Overdose treatment: Naloxone
Hydromorphone
Use: Moderate to severe pain, Addiction potential: High, Overdose treatment: Naloxone
Meperidine
Use: Acute pain, Addiction potential: High, Overdose treatment: Naloxone
Diamorphine
Use: Severe pain, end of life care (outside the US), Addiction potential: Very High, Overdose treatment: Naloxone
Oxymorphone
Use: Severe pain, Addiction potential: High, Overdose treatment: Naloxone
Tapentadol
Use: Moderate to severe pain, Addiction potential: Moderate, Overdose treatment: Naloxone
Pentazocine
Use: Moderate to severe pain, Addiction potential: Moderate, Overdose treatment: Naloxone
Butorphanol
Use: Moderate to severe pain, migraine, Addiction potential: Moderate, Overdose treatment: Naloxone
Levorphanol
Use: Moderate to severe pain, Addiction potential: High, Overdose treatment: Naloxone
Loperamide
Use: Diarrhea treatment, Addiction potential: Low (when used as directed), Overdose treatment: Naloxone (rarely necessary)
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