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Psychedelic-Assisted Psychotherapy

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MDMA (3,4-Methylenedioxymethamphetamine)

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Potential therapeutic uses include treatment for PTSD, social anxiety in autistic adults, and anxiety associated with life-threatening illnesses. Research is in Phase 3 clinical trials indicating promising results.

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Psilocybin

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Potential therapeutic uses include treatment for major depression, end-of-life psychological distress, and substance use disorders. Research includes several completed and ongoing studies indicating significant antidepressant effects.

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LSD (Lysergic acid diethylamide)

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Potential therapeutic uses include treatment for anxiety associated with life-threatening diseases, chronic pain, and substance use disorders. Research is in early stages with some small-scale studies showing potential benefits.

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DMT (Dimethyltryptamine)

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Potential therapeutic uses include treatment for depression, anxiety, and substance use disorders. Research is limited but growing with some promising results in early-stage clinical studies.

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Ayahuasca

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Potential therapeutic uses include treatment for addiction, depression, and PTSD. Research is sparse with more anthropological and observational studies than clinical trials but has indicated potential benefits.

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Ketamine

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Potential therapeutic uses include treatment for treatment-resistant depression, acute suicidal ideation, and chronic pain. Research includes FDA approval for a nasal-spray version for depression and various ongoing studies.

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Ibogaine

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Potential therapeutic uses include treatment for opioid and other substance addictions. Research is very limited and comes primarily from case studies and observational reports, with significant safety concerns.

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Mescaline

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Potential therapeutic uses include treatment for alcoholism and depression. Research is historical and currently very limited, with few contemporary studies on its therapeutic potential.

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Cannabidiol (CBD)

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Potential therapeutic uses include treatment for epilepsy, anxiety, and chronic pain. Research includes FDA approval for the treatment of certain types of epilepsy, with numerous ongoing studies.

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Salvinorin A

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Potential therapeutic uses include treatment for addiction, mood disorders, and cognitive enhancement. Research is preliminary, with animal studies and small-scale human research indicating unique pharmacological properties.

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