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Psychedelic-Assisted Psychotherapy
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MDMA (3,4-Methylenedioxymethamphetamine)
Potential therapeutic uses include treatment for PTSD, social anxiety in autistic adults, and anxiety associated with life-threatening illnesses. Research is in Phase 3 clinical trials indicating promising results.
Psilocybin
Potential therapeutic uses include treatment for major depression, end-of-life psychological distress, and substance use disorders. Research includes several completed and ongoing studies indicating significant antidepressant effects.
LSD (Lysergic acid diethylamide)
Potential therapeutic uses include treatment for anxiety associated with life-threatening diseases, chronic pain, and substance use disorders. Research is in early stages with some small-scale studies showing potential benefits.
DMT (Dimethyltryptamine)
Potential therapeutic uses include treatment for depression, anxiety, and substance use disorders. Research is limited but growing with some promising results in early-stage clinical studies.
Ayahuasca
Potential therapeutic uses include treatment for addiction, depression, and PTSD. Research is sparse with more anthropological and observational studies than clinical trials but has indicated potential benefits.
Ketamine
Potential therapeutic uses include treatment for treatment-resistant depression, acute suicidal ideation, and chronic pain. Research includes FDA approval for a nasal-spray version for depression and various ongoing studies.
Ibogaine
Potential therapeutic uses include treatment for opioid and other substance addictions. Research is very limited and comes primarily from case studies and observational reports, with significant safety concerns.
Mescaline
Potential therapeutic uses include treatment for alcoholism and depression. Research is historical and currently very limited, with few contemporary studies on its therapeutic potential.
Cannabidiol (CBD)
Potential therapeutic uses include treatment for epilepsy, anxiety, and chronic pain. Research includes FDA approval for the treatment of certain types of epilepsy, with numerous ongoing studies.
Salvinorin A
Potential therapeutic uses include treatment for addiction, mood disorders, and cognitive enhancement. Research is preliminary, with animal studies and small-scale human research indicating unique pharmacological properties.
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