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Monoamine Oxidase Inhibitors (MAOIs)
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Phenelzine
Uses: Depression, Anxiety, Panic Disorders. Dietary Restrictions: Tyramine-rich foods. Side Effects: Hypertension, Weight gain, Insomnia.
Tranylcypromine
Uses: Depression, Anxiety Disorders. Dietary Restrictions: Tyramine-rich foods, caffeine. Side Effects: Insomnia, Hypertensive crisis, Orthostatic hypotension.
Isocarboxazid
Uses: Depression, Atypical Depression. Dietary Restrictions: Tyramine-rich foods. Side Effects: Drowsiness, Dizziness, Dry mouth.
Selegiline
Uses: Depression, Adjunct for Parkinson's disease. Dietary Restrictions: Less strict, but recommend avoiding large quantities of tyramine. Side Effects: Nausea, Joint pain, Hypertension (at higher doses).
Moclobemide
Uses: Depression, Social Anxiety. Dietary Restrictions: Less strict tyramine interaction, but caution advised. Side Effects: Insomnia, Headache, Gastrointestinal disturbances.
Rasagiline
Uses: Parkinson's disease. Dietary Restrictions: Tyramine-rich foods at high doses. Side Effects: Joint pain, Indigestion, Flu-like symptoms.
Safinamide
Uses: Parkinson's disease as add-on therapy. Dietary Restrictions: Tyramine-rich food at high doses. Side Effects: Hypertension, Dyskinesia, Visual disturbances.
Nialamide
Uses: Depression. Dietary Restrictions: Tyramine-rich foods. Side Effects: Hypotension, Insomnia, Weight gain.
Iproniazid
Uses: Depression (historically). Dietary Restrictions: Tyramine-rich foods. Side Effects: Elevated liver enzymes, Peripheral neuropathy, Dizziness.
Pargyline
Uses: Hypertension (historically). Dietary Restrictions: Tyramine-rich foods. Side Effects: Autoimmune problems, Tremor, Weight gain.
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