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Monoamine Oxidase Inhibitors (MAOIs)

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Phenelzine

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Uses: Depression, Anxiety, Panic Disorders. Dietary Restrictions: Tyramine-rich foods. Side Effects: Hypertension, Weight gain, Insomnia.

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Tranylcypromine

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Uses: Depression, Anxiety Disorders. Dietary Restrictions: Tyramine-rich foods, caffeine. Side Effects: Insomnia, Hypertensive crisis, Orthostatic hypotension.

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Isocarboxazid

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Uses: Depression, Atypical Depression. Dietary Restrictions: Tyramine-rich foods. Side Effects: Drowsiness, Dizziness, Dry mouth.

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Selegiline

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Uses: Depression, Adjunct for Parkinson's disease. Dietary Restrictions: Less strict, but recommend avoiding large quantities of tyramine. Side Effects: Nausea, Joint pain, Hypertension (at higher doses).

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Moclobemide

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Uses: Depression, Social Anxiety. Dietary Restrictions: Less strict tyramine interaction, but caution advised. Side Effects: Insomnia, Headache, Gastrointestinal disturbances.

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Rasagiline

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Uses: Parkinson's disease. Dietary Restrictions: Tyramine-rich foods at high doses. Side Effects: Joint pain, Indigestion, Flu-like symptoms.

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Safinamide

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Uses: Parkinson's disease as add-on therapy. Dietary Restrictions: Tyramine-rich food at high doses. Side Effects: Hypertension, Dyskinesia, Visual disturbances.

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Nialamide

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Uses: Depression. Dietary Restrictions: Tyramine-rich foods. Side Effects: Hypotension, Insomnia, Weight gain.

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Iproniazid

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Uses: Depression (historically). Dietary Restrictions: Tyramine-rich foods. Side Effects: Elevated liver enzymes, Peripheral neuropathy, Dizziness.

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Pargyline

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Uses: Hypertension (historically). Dietary Restrictions: Tyramine-rich foods. Side Effects: Autoimmune problems, Tremor, Weight gain.

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