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Depressive Disorders Pharmacotherapy
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Fluoxetine
Use: SSRI for major depression, OCD, bulimia. Side effects: Insomnia, sexual dysfunction, serotonin syndrome.
Sertraline
Use: SSRI for depression, PTSD, OCD, social anxiety. Side effects: Gastrointestinal issues, sexual dysfunction, increased bleeding risk with anticoagulants.
Citalopram
Use: SSRI for depression. Side effects: Nausea, sexual dysfunction, QT prolongation.
Escitalopram
Use: SSRI for major depressive disorder and generalized anxiety disorder. Side effects: Nausea, headache, sexual dysfunction.
Venlafaxine
Use: SNRI for depression, generalized anxiety, panic disorder. Side effects: Hypertension, withdrawal symptoms, serotonin syndrome.
Duloxetine
Use: SNRI for depression, diabetic peripheral neuropathy pain. Side effects: Nausea, dry mouth, hepatotoxicity.
Bupropion
Use: NDRI for depression, smoking cessation. Side effects: Insomnia, dry mouth, seizure risk at high doses.
Mirtazapine
Use: Tetracyclic antidepressant for depression. Side effects: Sedation, increased appetite, weight gain.
Trazodone
Use: SARI for depression with insomnia. Side effects: Sedation, orthostatic hypotension, priapism.
Amitriptyline
Use: TCA for depression, neuropathic pain. Side effects: Anticholinergic effects, orthostatic hypotension, cardiac toxicity.
Nortriptyline
Use: TCA for depression. Side effects: Less anticholinergic than other TCAs, cardiotoxicity, sedation.
Clomipramine
Use: TCA for OCD and depression. Side effects: Anticholinergic effects, seizure risk, sexual dysfunction.
Imipramine
Use: TCA for depression and childhood enuresis. Side effects: Anticholinergic effects, orthostatic hypotension, suicidal thoughts or other mood changes.
Phenelzine
Use: MAOI for depression. Side effects: Dietary restrictions to avoid hypertensive crisis, weight gain, sexual dysfunction.
Tranylcypromine
Use: MAOI for depression. Side effects: Insomnia, hypertensive crisis if combined with tyramine-rich food, weight gain.
Isocarboxazid
Use: MAOI for depression. Side effects: Dizziness, orthostatic hypotension, dietary restrictions due to tyramine interaction.
Selegiline
Use: MAOI for depression, also used in Parkinson's disease. Side effects: Orthostatic hypotension, insomnia, hypertensive crisis with tyramine.
Vortioxetine
Use: Atypical antidepressant for major depressive disorder. Side effects: Nausea, vomiting, sexual dysfunction.
Agomelatine
Use: Atypical antidepressant, melatonin receptor agonist. Side effects: Headache, hepatotoxicity, contraindicated in patients with liver disease.
Desvenlafaxine
Use: SNRI for major depressive disorder. Side effects: Nausea, dry mouth, dizziness.
Levomilnacipran
Use: SNRI for major depressive disorder. Side effects: Elevated heart rate, urinary hesitation, sexual dysfunction.
Vilazodone
Use: Atypical antidepressant for major depressive disorder. Side effects: Diarrhea, nausea, minimal sexual dysfunction.
Reboxetine
Use: NRI for major depressive disorder. Side effects: Dry mouth, constipation, increased heart rate.
Maprotiline
Use: Tetracyclic antidepressant for major depression with a high level of anxiety. Side effects: Sedation, anticholinergic effects, risk of seizures.
Nefazodone
Use: SARI for major depressive disorder. Side effects: Sedation, headache, rare cases of liver failure.
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