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Depressive Disorders Pharmacotherapy

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Fluoxetine

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Use: SSRI for major depression, OCD, bulimia. Side effects: Insomnia, sexual dysfunction, serotonin syndrome.

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Sertraline

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Use: SSRI for depression, PTSD, OCD, social anxiety. Side effects: Gastrointestinal issues, sexual dysfunction, increased bleeding risk with anticoagulants.

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Citalopram

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Use: SSRI for depression. Side effects: Nausea, sexual dysfunction, QT prolongation.

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Escitalopram

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Use: SSRI for major depressive disorder and generalized anxiety disorder. Side effects: Nausea, headache, sexual dysfunction.

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Venlafaxine

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Use: SNRI for depression, generalized anxiety, panic disorder. Side effects: Hypertension, withdrawal symptoms, serotonin syndrome.

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Duloxetine

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Use: SNRI for depression, diabetic peripheral neuropathy pain. Side effects: Nausea, dry mouth, hepatotoxicity.

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Bupropion

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Use: NDRI for depression, smoking cessation. Side effects: Insomnia, dry mouth, seizure risk at high doses.

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Mirtazapine

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Use: Tetracyclic antidepressant for depression. Side effects: Sedation, increased appetite, weight gain.

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Trazodone

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Use: SARI for depression with insomnia. Side effects: Sedation, orthostatic hypotension, priapism.

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Amitriptyline

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Use: TCA for depression, neuropathic pain. Side effects: Anticholinergic effects, orthostatic hypotension, cardiac toxicity.

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Nortriptyline

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Use: TCA for depression. Side effects: Less anticholinergic than other TCAs, cardiotoxicity, sedation.

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Clomipramine

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Use: TCA for OCD and depression. Side effects: Anticholinergic effects, seizure risk, sexual dysfunction.

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Imipramine

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Use: TCA for depression and childhood enuresis. Side effects: Anticholinergic effects, orthostatic hypotension, suicidal thoughts or other mood changes.

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Phenelzine

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Use: MAOI for depression. Side effects: Dietary restrictions to avoid hypertensive crisis, weight gain, sexual dysfunction.

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Tranylcypromine

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Use: MAOI for depression. Side effects: Insomnia, hypertensive crisis if combined with tyramine-rich food, weight gain.

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Isocarboxazid

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Use: MAOI for depression. Side effects: Dizziness, orthostatic hypotension, dietary restrictions due to tyramine interaction.

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Selegiline

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Use: MAOI for depression, also used in Parkinson's disease. Side effects: Orthostatic hypotension, insomnia, hypertensive crisis with tyramine.

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Vortioxetine

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Use: Atypical antidepressant for major depressive disorder. Side effects: Nausea, vomiting, sexual dysfunction.

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Agomelatine

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Use: Atypical antidepressant, melatonin receptor agonist. Side effects: Headache, hepatotoxicity, contraindicated in patients with liver disease.

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Desvenlafaxine

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Use: SNRI for major depressive disorder. Side effects: Nausea, dry mouth, dizziness.

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Levomilnacipran

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Use: SNRI for major depressive disorder. Side effects: Elevated heart rate, urinary hesitation, sexual dysfunction.

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Vilazodone

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Use: Atypical antidepressant for major depressive disorder. Side effects: Diarrhea, nausea, minimal sexual dysfunction.

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Reboxetine

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Use: NRI for major depressive disorder. Side effects: Dry mouth, constipation, increased heart rate.

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Maprotiline

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Use: Tetracyclic antidepressant for major depression with a high level of anxiety. Side effects: Sedation, anticholinergic effects, risk of seizures.

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Nefazodone

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Use: SARI for major depressive disorder. Side effects: Sedation, headache, rare cases of liver failure.

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