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Adjuvants in Vaccinology
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Flashcards
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Aluminum Salts
Mechanism of action: They act as an antigen depot, slowly releasing antigen to enhance antigen uptake and promote the activation of antigen-presenting cells. Use: Widely used in vaccines like Hepatitis B and HPV vaccines.
MF59
Mechanism of action: An oil-in-water emulsion that enhances immune response by targeting antigens to antigen-presenting cells and promoting cell-mediated immunity. Use: Used in influenza vaccines.
CpG Oligodeoxynucleotides
Mechanism of action: They mimic bacterial DNA and trigger immune cells via toll-like receptor 9 (TLR9), enhancing both innate and adaptive immune responses. Use: Being investigated for use in vaccines against cancer, allergies, and infectious diseases.
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