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The Complement System
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C1 complex
Initiates the classical complement pathway
C4b2a complex
Acts as a C3 convertase in the classical and lectin pathways
C3b
Opsonizes bacteria, making them easier to phagocytose
C5 convertase
Cleaves C5 into C5a and C5b, initiating the terminal pathway
C5a
Functions as a potent inflammatory mediator
Membrane Attack Complex (MAC)
Forms a pore in the membranes of pathogens, leading to cell lysis
Factor H and I
Regulate the complement system to prevent damage to host cells
Properdin
Stabilizes the alternative pathway C3 convertase
Mannose-binding lectin (MBL)
Initiates the lectin complement pathway
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