Discover published sets by community

Occurs during lymphocyte development in thymus and bone marrow, eliminating self-reactive T and B cells to prevent autoimmunity. Examples: Negative selection of T cells in thymus, Clonal deletion of B cells in bone marrow.

Occurs when self-reactive lymphocytes are present but ignore self-antigens due to low antigen concentration or inaccessibility of antigen. Examples: Immune privilege in the brain and eyes, Poor lymphocyte accessibility to certain self-antigens.

A state of unresponsiveness to antigen stimulation, effectively inactivating self-reactive T or B cells when costimulatory molecules are absent. Examples: T cell anergy when only the TCR is engaged without CD28, B cell anergy with engagement of BCR without helper T cell interaction.

Specialized T cells that maintain tolerance to self-antigens and prevent autoimmune disease by controlling the immune response. Examples: Suppression of effector T cell function, Modulation of dendritic cell (DC) maturation and antigen presentation.