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B Cell Maturation
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Flashcards
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Immature B Cell
Complete B cell receptor is expressed; cells undergo negative selection.
Pre-B Cell
Expression of the pre-B cell receptor; light chain rearrangement begins.
Activated B Cell
B cell binds antigen, receives T-cell help, and undergoes clonal expansion and differentiation.
Mature Naive B Cell
B cell has passed negative selection and expresses IgM and IgD on the surface.
Pro-B Cell
Earliest identifiable B cell stage; heavy chain rearrangement is occurring.
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