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B Cell Maturation

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Immature B Cell

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Complete B cell receptor is expressed; cells undergo negative selection.

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Pre-B Cell

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Expression of the pre-B cell receptor; light chain rearrangement begins.

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Activated B Cell

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B cell binds antigen, receives T-cell help, and undergoes clonal expansion and differentiation.

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Mature Naive B Cell

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B cell has passed negative selection and expresses IgM and IgD on the surface.

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Pro-B Cell

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Earliest identifiable B cell stage; heavy chain rearrangement is occurring.

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