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Function: Converts prothrombin to thrombin in the presence of Factor V. Disorders: Factor X deficiency.

Function: Converts to fibrin during clotting. Disorders: Afibrinogenemia, Hypofibrinogenemia, Dysfibrinogenemia.

Function: Cofactor for Factor IX, aids in activating Factor X. Disorders: Hemophilia A.

Function: Initiates coagulation in the extrinsic pathway. Disorders: Factor VII deficiency.

Function: Activates Factor IX. Disorders: Hemophilia C (Factor XI deficiency).

Function: Binds to Factor VIII and platelets, aiding in platelet adhesion. Disorders: Von Willebrand Disease.

Function: Converted to thrombin in clotting process. Disorders: Prothrombin deficiency, Hypoprothrombinemia.

Function: Activates Factor X with help from Factor VIII. Disorders: Hemophilia B.

Function: Works with high-molecular-weight kininogen to activate Factor XII; involved in inflammation and blood pressure control. Disorders: Prekallikrein deficiency may lead to prolonged aPTT without bleeding.

Function: Cofactor for the conversion of prothrombin to thrombin. Disorders: Parahemophilia, Factor V Leiden.

Function: Stabilizes the fibrin clot by cross-linking fibrin. Disorders: Factor XIII deficiency can lead to severe bleeding disorders.

Function: Initiates extrinsic pathway of coagulation. Disorders: Tissue Factor deficiency is rare but can lead to bleeding.