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Pathology of Gynecologic Diseases

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Endometriosis

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Pathophysiology: Presence of endometrial tissue outside the uterine cavity causing an inflammatory reaction. Symptoms: Pelvic pain, dysmenorrhea, and infertility.

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Gestational Trophoblastic Disease

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Pathophysiology: Abnormal growth of placental tissue inside the uterus during or after pregnancy. Symptoms: Vaginal bleeding, high levels of hCG, and absence of fetal heart tones.

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Vaginitis

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Pathophysiology: Inflammation of the vagina due to infections or hormonal changes. Symptoms: Vaginal discharge, itchiness, and burning.

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Ovarian Cysts

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Pathophysiology: Fluid-filled sacs within or on the surface of an ovary. Symptoms: Pelvic pain, bloating, and menstrual irregularities.

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Cervical Dysplasia

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Pathophysiology: Abnormal growth of cells on the surface of the cervix that could lead to cervical cancer. Symptoms: Usually asymptomatic but may be detected on Pap smear.

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Uterine Fibroids

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Pathophysiology: Benign smooth muscle tumors of the uterus. Symptoms: Menorrhagia, pelvic pressure or pain, and reproductive issues.

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Polycystic Ovary Syndrome (PCOS)

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Pathophysiology: Hormonal imbalance leading to anovulation and cyst formation in ovaries. Symptoms: Irregular menstrual periods, hirsutism, obesity, and infertility.

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Pelvic Inflammatory Disease (PID)

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Pathophysiology: Infection of the female reproductive organs, often caused by STIs. Symptoms: Lower abdominal pain, fever, foul-smelling vaginal discharge, and pain during intercourse or urination.

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Adenomyosis

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Pathophysiology: Growth of endometrial tissue into the uterine muscle. Symptoms: Menorrhagia, dysmenorrhea, and enlarged uterus.

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Vulvodynia

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Pathophysiology: Chronic vulvar pain without an identifiable cause. Symptoms: Vulvar discomfort, burning, itching, or irritation.

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Menorrhagia

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Pathophysiology: Excessively heavy or prolonged menstrual bleeding. Symptoms: Menstrual periods with abnormally heavy or prolonged bleeding.

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Prolapsed Uterus

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Pathophysiology: Descent of the uterus into or outside of the vaginal canal, occurring when pelvic floor muscles weaken. Symptoms: Feeling of heaviness or pulling in the pelvis, difficulty with urination, and uterine tissue protruding from vagina.

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Cervicitis

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Pathophysiology: Inflammation of the cervix, often due to infection. Symptoms: Vaginal discharge, pelvic pain, and bleeding between periods or after sexual intercourse.

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Premature Ovarian Insufficiency (POI)

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Pathophysiology: Loss of normal ovarian function before age 40. Symptoms: Irregular or missed periods, hot flashes, and infertility.

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Ovarian Cancer

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Pathophysiology: Malignant transformation and proliferation of ovarian cells. Symptoms: Abdominal bloating, early satiety, pelvic pain, and urinary urgency or frequency.

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