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Pathology of Gynecologic Diseases
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Endometriosis
Pathophysiology: Presence of endometrial tissue outside the uterine cavity causing an inflammatory reaction. Symptoms: Pelvic pain, dysmenorrhea, and infertility.
Gestational Trophoblastic Disease
Pathophysiology: Abnormal growth of placental tissue inside the uterus during or after pregnancy. Symptoms: Vaginal bleeding, high levels of hCG, and absence of fetal heart tones.
Vaginitis
Pathophysiology: Inflammation of the vagina due to infections or hormonal changes. Symptoms: Vaginal discharge, itchiness, and burning.
Ovarian Cysts
Pathophysiology: Fluid-filled sacs within or on the surface of an ovary. Symptoms: Pelvic pain, bloating, and menstrual irregularities.
Cervical Dysplasia
Pathophysiology: Abnormal growth of cells on the surface of the cervix that could lead to cervical cancer. Symptoms: Usually asymptomatic but may be detected on Pap smear.
Uterine Fibroids
Pathophysiology: Benign smooth muscle tumors of the uterus. Symptoms: Menorrhagia, pelvic pressure or pain, and reproductive issues.
Polycystic Ovary Syndrome (PCOS)
Pathophysiology: Hormonal imbalance leading to anovulation and cyst formation in ovaries. Symptoms: Irregular menstrual periods, hirsutism, obesity, and infertility.
Pelvic Inflammatory Disease (PID)
Pathophysiology: Infection of the female reproductive organs, often caused by STIs. Symptoms: Lower abdominal pain, fever, foul-smelling vaginal discharge, and pain during intercourse or urination.
Adenomyosis
Pathophysiology: Growth of endometrial tissue into the uterine muscle. Symptoms: Menorrhagia, dysmenorrhea, and enlarged uterus.
Vulvodynia
Pathophysiology: Chronic vulvar pain without an identifiable cause. Symptoms: Vulvar discomfort, burning, itching, or irritation.
Menorrhagia
Pathophysiology: Excessively heavy or prolonged menstrual bleeding. Symptoms: Menstrual periods with abnormally heavy or prolonged bleeding.
Prolapsed Uterus
Pathophysiology: Descent of the uterus into or outside of the vaginal canal, occurring when pelvic floor muscles weaken. Symptoms: Feeling of heaviness or pulling in the pelvis, difficulty with urination, and uterine tissue protruding from vagina.
Cervicitis
Pathophysiology: Inflammation of the cervix, often due to infection. Symptoms: Vaginal discharge, pelvic pain, and bleeding between periods or after sexual intercourse.
Premature Ovarian Insufficiency (POI)
Pathophysiology: Loss of normal ovarian function before age 40. Symptoms: Irregular or missed periods, hot flashes, and infertility.
Ovarian Cancer
Pathophysiology: Malignant transformation and proliferation of ovarian cells. Symptoms: Abdominal bloating, early satiety, pelvic pain, and urinary urgency or frequency.
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