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Infectious Diseases in Immunocompromised Individuals
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Aspergillosis
High risk of invasive disease. Treatment includes voriconazole and may require surgical debridement.
Severe Acute Respiratory Syndrome (SARS)
Can lead to severe pneumonia and acute respiratory distress syndrome (ARDS). Treatment is mainly supportive; antivirals and steroids remain controversial.
Tuberculosis (TB)
May present atypically and disseminate more readily. Treatment involves longer courses of antibiotics and monitoring for drug resistance.
Malaria
More severe disease and complications in immunocompromised individuals. Antimalarial drugs must be chosen based on resistance patterns and side effects.
Dengue Fever
Can progress to severe dengue, which is life-threatening. Mostly supportive care; monitoring for complications like hemorrhagic fever is critical.
Chikungunya
May cause chronic joint pain and arthritis-like symptoms. No specific treatment; management focuses on symptom relief.
Norovirus
Can cause more severe and prolonged gastroenteritis. No specific treatment; rehydration and supportive care are key.
Pneumocystis Pneumonia (PCP)
Can lead to severe respiratory distress and may progress rapidly. Trimethoprim-sulfamethoxazole is the treatment of choice but may need alternatives due to high rates of adverse reactions.
Cytomegalovirus (CMV)
Can cause retinitis, colitis, encephalitis, and pneumonitis. Antiviral therapy with ganciclovir or valganciclovir is required, and maintenance therapy may be indicated.
Influenza
Can cause severe complications like pneumonia. Antiviral drugs such as oseltamivir should be initiated as soon as possible.
Cryptococcal Meningitis
Increased risk of severe meningitis. Treatment involves extended courses of antifungals such as amphotericin B and flucytosine.
Candidiasis
Higher risk of disseminated infection. Treatment includes fluconazole or an echinocandin, depending on the severity and species involved.
Hepatitis C
Higher chance of chronic infection and liver complications. Direct-acting antivirals are effective but require careful monitoring.
West Nile Virus
Severe neurological disease more common in immunocompromised hosts. Treatment is supportive, and prevention involves mosquito control.
HIV/AIDS
Increased susceptibility to opportunistic infections and malignancies. Antiretroviral therapy must be carefully selected to minimize interactions and resistance.
Ebola Virus Disease
Immunocompromised patients are at higher risk of severe disease and death. Treatment is primarily supportive, with experimental therapies under investigation.
Histoplasmosis
Can result in disseminated infection. Antifungal treatment such as itraconazole or amphotericin B is required, sometimes for prolonged periods.
Invasive Pneumococcal Disease
Increased risk of bacteremia and meningitis. Antibiotic therapy must be prompt, and vaccination is critical for prevention.
Varicella Zoster Virus (Shingles)
Can lead to disseminated disease and severe complications. Antiviral treatment with acyclovir, valacyclovir, or famciclovir is required.
Zika Virus
Immunocompromised patients may have prolonged viremia. There is no specific treatment, and care is supportive.
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