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Infectious Diseases in Immunocompromised Individuals

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Aspergillosis

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High risk of invasive disease. Treatment includes voriconazole and may require surgical debridement.

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Severe Acute Respiratory Syndrome (SARS)

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Can lead to severe pneumonia and acute respiratory distress syndrome (ARDS). Treatment is mainly supportive; antivirals and steroids remain controversial.

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Tuberculosis (TB)

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May present atypically and disseminate more readily. Treatment involves longer courses of antibiotics and monitoring for drug resistance.

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Malaria

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More severe disease and complications in immunocompromised individuals. Antimalarial drugs must be chosen based on resistance patterns and side effects.

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Dengue Fever

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Can progress to severe dengue, which is life-threatening. Mostly supportive care; monitoring for complications like hemorrhagic fever is critical.

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Chikungunya

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May cause chronic joint pain and arthritis-like symptoms. No specific treatment; management focuses on symptom relief.

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Norovirus

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Can cause more severe and prolonged gastroenteritis. No specific treatment; rehydration and supportive care are key.

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Pneumocystis Pneumonia (PCP)

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Can lead to severe respiratory distress and may progress rapidly. Trimethoprim-sulfamethoxazole is the treatment of choice but may need alternatives due to high rates of adverse reactions.

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Cytomegalovirus (CMV)

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Can cause retinitis, colitis, encephalitis, and pneumonitis. Antiviral therapy with ganciclovir or valganciclovir is required, and maintenance therapy may be indicated.

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Influenza

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Can cause severe complications like pneumonia. Antiviral drugs such as oseltamivir should be initiated as soon as possible.

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Cryptococcal Meningitis

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Increased risk of severe meningitis. Treatment involves extended courses of antifungals such as amphotericin B and flucytosine.

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Candidiasis

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Higher risk of disseminated infection. Treatment includes fluconazole or an echinocandin, depending on the severity and species involved.

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Hepatitis C

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Higher chance of chronic infection and liver complications. Direct-acting antivirals are effective but require careful monitoring.

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West Nile Virus

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Severe neurological disease more common in immunocompromised hosts. Treatment is supportive, and prevention involves mosquito control.

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HIV/AIDS

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Increased susceptibility to opportunistic infections and malignancies. Antiretroviral therapy must be carefully selected to minimize interactions and resistance.

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Ebola Virus Disease

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Immunocompromised patients are at higher risk of severe disease and death. Treatment is primarily supportive, with experimental therapies under investigation.

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Histoplasmosis

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Can result in disseminated infection. Antifungal treatment such as itraconazole or amphotericin B is required, sometimes for prolonged periods.

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Invasive Pneumococcal Disease

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Increased risk of bacteremia and meningitis. Antibiotic therapy must be prompt, and vaccination is critical for prevention.

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Varicella Zoster Virus (Shingles)

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Can lead to disseminated disease and severe complications. Antiviral treatment with acyclovir, valacyclovir, or famciclovir is required.

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Zika Virus

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Immunocompromised patients may have prolonged viremia. There is no specific treatment, and care is supportive.

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