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Symptoms: Changes in temperament, coordination, and the ability to stand. Prognosis: Terminal. Impact on Brain: Spongiosis, gliosis, and amyloid plaque formation.

Symptoms: Behavioral changes, ataxia, weight loss. Prognosis: Terminal. Impact on Brain: Spongiform change similar to other prion diseases affecting ungulates.

Symptoms: Weight loss, behavioral changes, excessive salivation in affected animals. Prognosis: Terminal. Impact on Brain: Spongiform changes and gliosis, similar to BSE.

Symptoms: Behavioral changes, ataxia, hypersensitivity. Prognosis: Terminal. Impact on Brain: Spongiform encephalopathy characterized by vacuolation of brain neurons.

Symptoms: Behavioral changes, ataxia, aggression or lethargy. Prognosis: Terminal. Impact on Brain: Prion-induced neurodegeneration causing spongiform changes.

Symptoms: Tremors, ataxia, emotional instability. Prognosis: Terminal, usually within a year of onset. Impact on Brain: Severe spongiform change, neuronal loss, and gliosis.

Symptoms: Insomnia, motor dysfunction, cognitive impairment. Prognosis: Terminal, typically within 8-18 months. Impact on Brain: Thalamic degeneration, similar to FFI but without a clear genetic cause.

Symptoms: Behavioral changes, itching, loss of coordination in sheep. Prognosis: Terminal. Impact on Brain: Spongiform change, astrocytic gliosis without significant neuronal loss.

Symptoms: Rapidly progressive dementia, muscle stiffness, myoclonus. Prognosis: Terminal, usually within one year. Impact on Brain: Spongiform changes, neuronal loss, and gliosis without inflammatory response.

Symptoms: Ataxia, dementia, speech abnormalities. Prognosis: Terminal, course of disease ranges from 2 to 10 years. Impact on Brain: Multifocal spongiform degeneration and amyloid plaque deposition.

Symptoms: Psychiatric disturbances, sensory symptoms, ataxia. Prognosis: Terminal, typically lasts longer than CJD. Impact on Brain: Similar to CJD with the presence of amyloid plaques in the brain.

Symptoms: Insomnia, hallucinations, rapid weight loss. Prognosis: Terminal, typically within a year or two. Impact on Brain: Atrophy of the thalamus, with spongiform degeneration.

Symptoms: Seizures, liver dysfunction, progressive neurological deterioration. Prognosis: Terminal, often in childhood. Impact on Brain: Neuronal degeneration, gliosis in the brain, but not typically spongiform change.

Symptoms: Behavioral changes, ataxia, hyperexcitability in affected mink. Prognosis: Terminal. Impact on Brain: Spongiform degeneration, astrocyte proliferation.