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Biological Membranes

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Membrane asymmetry

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The distinct composition of the inner and outer leaflets of the bilayer, important for membrane curvature, vesicle formation, and cell signaling.

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Sphingosine-1-phosphate (S1P)

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A signaling lipid derived from the sphingolipid pathway that is involved in processes such as cell growth, survival, and migration.

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Ceramide-1-phosphate (C1P)

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A bioactive lipid involved in cell survival and inflammatory processes, derived from ceramide.

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Flippases and scramblases

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Enzymes that facilitate the movement of phospholipids between leaflets of the bilayer, maintaining asymmetric distribution of lipids.

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Inositol phospholipids

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Minor components of cell membranes, they serve as sources for second messengers in signal transduction.

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Membrane scaffold proteins

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Proteins that support cell membrane structure, they help in organizing membrane components and can influence membrane curvature.

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Ion channels

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Proteins that allow the passage of specific ions across the membrane, contributing to the membrane potential and signal transduction.

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Sterol-sensing domains

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Protein domains that bind cholesterol or other sterols, they mediate cellular responses to changing sterol concentrations.

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Desmosomes

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Cell structures composed of cadherins and other proteins that link two cells together, stabilizing tissues against mechanical stress.

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Caveolae

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Invaginations in the cell membrane rich in cholesterol and sphingolipids, they are involved in signal transduction and endocytosis.

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Anchored membrane proteins

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Proteins that are covalently attached to fatty acids or prenyl groups which tether them to the cell membrane.

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Plasmalogens

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A type of phospholipid with a vinyl ether bond at the sn-1 position, they are involved in membrane fusion and as antioxidants.

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Cholesterol

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Stabilizes membrane fluidity across temperatures, prevents crystallization of fatty acids, found in animal cell membranes.

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Gap junctions

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Specialized intercellular connections that allow for the passage of ions and small molecules between cells, facilitating communication.

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Fatty acids

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Components of phospholipids, they vary in chain length and saturation, influencing membrane fluidity and permeability.

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PIP2 (Phosphatidylinositol 4,5-bisphosphate)

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A minor component that plays a key role in signal transduction pathways, serving as a precursor for secondary messengers.

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Arachidonic acid

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A fatty acid derived from the phospholipids of cell membranes, it is a precursor to eicosanoids, which are signaling molecules.

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Integral membrane proteins

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Embedded within the membrane, they can act as channels, receptors or enzymes and are involved in transport and signaling.

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Sphingomyelins

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Type of sphingolipid found in the plasma membrane, they contribute to the structural integrity and modulate the fluidity.

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Phospholipids

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Primary component of cell membranes, form bilayers with hydrophilic heads outward and hydrophobic tails inward, provide fluidity and permeability.

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Carbohydrates

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Attached to lipids (glycolipids) or proteins (glycoproteins) on the extracellular side; function in cell-cell recognition and adhesion.

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Glycoproteins

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Proteins with carbohydrate chains attached, they play a role in cell-cell interactions and serve as recognition sites.

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Aquaporins

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Channel proteins that facilitate water transport across cell membranes, crucial for fluid balance and osmotic regulation.

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Eicosanoids

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Signaling molecules derived from arachidonic acid, they have roles in inflammation, immunity, and as messengers in the central nervous system.

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Ceramides

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A type of sphingolipid, believed to participate in cell signaling and apoptosis.

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Polyunsaturated fatty acids (PUFAs)

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Fatty acids with multiple double bonds, they influence membrane fluidity and are precursors to bioactive lipid mediators.

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Glycolipids

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Lipids with carbohydrate chains attached, function in maintaining stability of the membrane and in cell-cell recognition.

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Receptors

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Membrane proteins that bind signaling molecules and initiate cellular responses, they are crucial for intercellular communication.

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Cardiolipin

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A double phospholipid linked by a glycerol, predominantly found in the inner mitochondrial membrane, involved in stabilizing protein complexes and signaling.

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Peripheral membrane proteins

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Attached to the surface of the membrane, they are often associated with the intracellular side and play roles in signaling and maintaining the cell's shape.

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Tight junctions

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Form impermeable barriers between cells, preventing passage of substances between cells, contributing to tissue compartmentalization.

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Proteins

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Perform a wide range of functions including signal transduction, transport, enzymatic activity, and cell recognition.

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Transporters

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Integral proteins that mediate the passage of molecules across the membrane, they can operate through facilitated diffusion or active transport.

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Lipid rafts

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Microdomains within plasma membranes rich in cholesterol, sphingolipids, and certain proteins; they function in membrane trafficking and signal transduction.

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Vitamin E (Tocopherols)

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A lipid-soluble antioxidant that protects cell membranes from oxidative damage and supports membrane stability.

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