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Biological Membranes
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Phospholipids
Primary component of cell membranes, form bilayers with hydrophilic heads outward and hydrophobic tails inward, provide fluidity and permeability.
Cholesterol
Stabilizes membrane fluidity across temperatures, prevents crystallization of fatty acids, found in animal cell membranes.
Proteins
Perform a wide range of functions including signal transduction, transport, enzymatic activity, and cell recognition.
Carbohydrates
Attached to lipids (glycolipids) or proteins (glycoproteins) on the extracellular side; function in cell-cell recognition and adhesion.
Glycolipids
Lipids with carbohydrate chains attached, function in maintaining stability of the membrane and in cell-cell recognition.
Glycoproteins
Proteins with carbohydrate chains attached, they play a role in cell-cell interactions and serve as recognition sites.
Integral membrane proteins
Embedded within the membrane, they can act as channels, receptors or enzymes and are involved in transport and signaling.
Peripheral membrane proteins
Attached to the surface of the membrane, they are often associated with the intracellular side and play roles in signaling and maintaining the cell's shape.
Ion channels
Proteins that allow the passage of specific ions across the membrane, contributing to the membrane potential and signal transduction.
Transporters
Integral proteins that mediate the passage of molecules across the membrane, they can operate through facilitated diffusion or active transport.
Aquaporins
Channel proteins that facilitate water transport across cell membranes, crucial for fluid balance and osmotic regulation.
Receptors
Membrane proteins that bind signaling molecules and initiate cellular responses, they are crucial for intercellular communication.
Lipid rafts
Microdomains within plasma membranes rich in cholesterol, sphingolipids, and certain proteins; they function in membrane trafficking and signal transduction.
Flippases and scramblases
Enzymes that facilitate the movement of phospholipids between leaflets of the bilayer, maintaining asymmetric distribution of lipids.
Sphingomyelins
Type of sphingolipid found in the plasma membrane, they contribute to the structural integrity and modulate the fluidity.
Ceramides
A type of sphingolipid, believed to participate in cell signaling and apoptosis.
Anchored membrane proteins
Proteins that are covalently attached to fatty acids or prenyl groups which tether them to the cell membrane.
Desmosomes
Cell structures composed of cadherins and other proteins that link two cells together, stabilizing tissues against mechanical stress.
Gap junctions
Specialized intercellular connections that allow for the passage of ions and small molecules between cells, facilitating communication.
Tight junctions
Form impermeable barriers between cells, preventing passage of substances between cells, contributing to tissue compartmentalization.
Cardiolipin
A double phospholipid linked by a glycerol, predominantly found in the inner mitochondrial membrane, involved in stabilizing protein complexes and signaling.
Fatty acids
Components of phospholipids, they vary in chain length and saturation, influencing membrane fluidity and permeability.
PIP2 (Phosphatidylinositol 4,5-bisphosphate)
A minor component that plays a key role in signal transduction pathways, serving as a precursor for secondary messengers.
Caveolae
Invaginations in the cell membrane rich in cholesterol and sphingolipids, they are involved in signal transduction and endocytosis.
Arachidonic acid
A fatty acid derived from the phospholipids of cell membranes, it is a precursor to eicosanoids, which are signaling molecules.
Inositol phospholipids
Minor components of cell membranes, they serve as sources for second messengers in signal transduction.
Plasmalogens
A type of phospholipid with a vinyl ether bond at the sn-1 position, they are involved in membrane fusion and as antioxidants.
Sterol-sensing domains
Protein domains that bind cholesterol or other sterols, they mediate cellular responses to changing sterol concentrations.
Sphingosine-1-phosphate (S1P)
A signaling lipid derived from the sphingolipid pathway that is involved in processes such as cell growth, survival, and migration.
Ceramide-1-phosphate (C1P)
A bioactive lipid involved in cell survival and inflammatory processes, derived from ceramide.
Polyunsaturated fatty acids (PUFAs)
Fatty acids with multiple double bonds, they influence membrane fluidity and are precursors to bioactive lipid mediators.
Membrane asymmetry
The distinct composition of the inner and outer leaflets of the bilayer, important for membrane curvature, vesicle formation, and cell signaling.
Membrane scaffold proteins
Proteins that support cell membrane structure, they help in organizing membrane components and can influence membrane curvature.
Eicosanoids
Signaling molecules derived from arachidonic acid, they have roles in inflammation, immunity, and as messengers in the central nervous system.
Vitamin E (Tocopherols)
A lipid-soluble antioxidant that protects cell membranes from oxidative damage and supports membrane stability.
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