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Neurotransmitters and Receptors
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GABA
Function: Principal inhibitory neurotransmitter in the brain. Receptors: GABA₊ and GABA₋ receptors.
Serotonin
Function: Regulates mood, appetite, and sleep. Receptors: 5-HT1 to 5-HT7 with various subtypes.
Carbon monoxide
Function: Can function as a neurotransmitter, regulating synaptic transmission. Receptors: Soluble guanylate cyclase receptor (like nitric oxide).
Dopamine
Function: Involved in reward, motivation, and motor control among other pathways. Receptors: D1 to D5 dopamine receptors.
Leptin
Function: Signals the status of energy stores to the brain and regulates appetite. Receptors: Leptin receptor.
Peptide YY
Function: Reduces appetite and inhibits gastric motility. Receptors: Neuropeptide Y (NPY) receptors.
Neuropeptide Y
Function: Stimulates food intake and decreases energy expenditure. Receptors: NPY receptors Y1, Y2, Y4, Y5.
Orexin (Hypocretin)
Function: Promotes wakefulness and regulates appetite. Receptors: Orexin receptor 1 (OX1R) and Orexin receptor 2 (OX2R).
Vasopressin
Function: Regulates water retention in the kidneys and increases blood pressure. Receptors: V1a, V1b, and V2 receptors.
Somatostatin
Function: Inhibits the release of growth hormone and other hormones. Receptors: Somatostatin receptors (SSTRs) 1 through 5.
Epinephrine
Function: Also known as adrenaline, it enhances fight or flight response. Receptors: Alpha-1, alpha-2, beta-1, beta-2, and beta-3 adrenergic receptors.
Endorphins
Function: Reduce pain and induce feelings of pleasure. Receptors: Mu, delta, and kappa opioid receptors.
Corticotropin-releasing hormone (CRH)
Function: Stimulates secretion of adrenocorticotropic hormone (ACTH). Receptors: CRH receptors 1 and 2.
Acetylcholine
Function: Involved with muscle activation, attention, and arousal. Receptors: Nicotinic and muscarinic receptors.
Nitric oxide
Function: A retrograde neurotransmitter, modulating synaptic plasticity. Receptors: Soluble guanylate cyclase receptor.
Anandamide
Function: Plays a role in pain, appetite regulation, and mood. Receptors: CB1 and CB2 cannabinoids receptors.
Oxytocin
Function: Promotes bonding, social behavior and is involved in childbirth and lactation. Receptors: Oxytocin receptor.
Glutamate
Function: Major excitatory neurotransmitter in the central nervous system. Receptors: NMDA, AMPA, and kainate receptors.
Substance P
Function: Mediator of pain signals and inflammatory processes. Receptors: Neurokinin-1 (NK1) receptor.
Brain-derived neurotrophic factor (BDNF)
Function: Involved in neuron survival, growth, and differentiation. Receptors: TrkB receptor.
Norepinephrine
Function: Increases arousal and alertness, involved in fight or flight response. Receptors: alpha and beta adrenergic receptors.
Glycine
Function: Main inhibitory neurotransmitter in the spinal cord. Receptors: Glycine receptor.
Adenosine
Function: Generally inhibits neuronal activity and promotes sleep. Receptors: A1, A2A, A2B, and A3 receptors.
Histamine
Function: Involved in inflammatory response and regulation of stomach acid. Receptors: H1, H2, H3, and H4 receptors.
Insulin
Function: Regulates glucose uptake in the brain and affects satiety. Receptors: Insulin receptor.
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