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Neurotransmitters and Receptors

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GABA

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Function: Principal inhibitory neurotransmitter in the brain. Receptors: GABA₊ and GABA₋ receptors.

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Serotonin

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Function: Regulates mood, appetite, and sleep. Receptors: 5-HT1 to 5-HT7 with various subtypes.

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Carbon monoxide

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Function: Can function as a neurotransmitter, regulating synaptic transmission. Receptors: Soluble guanylate cyclase receptor (like nitric oxide).

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Dopamine

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Function: Involved in reward, motivation, and motor control among other pathways. Receptors: D1 to D5 dopamine receptors.

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Leptin

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Function: Signals the status of energy stores to the brain and regulates appetite. Receptors: Leptin receptor.

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Peptide YY

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Function: Reduces appetite and inhibits gastric motility. Receptors: Neuropeptide Y (NPY) receptors.

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Neuropeptide Y

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Function: Stimulates food intake and decreases energy expenditure. Receptors: NPY receptors Y1, Y2, Y4, Y5.

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Orexin (Hypocretin)

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Function: Promotes wakefulness and regulates appetite. Receptors: Orexin receptor 1 (OX1R) and Orexin receptor 2 (OX2R).

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Vasopressin

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Function: Regulates water retention in the kidneys and increases blood pressure. Receptors: V1a, V1b, and V2 receptors.

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Somatostatin

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Function: Inhibits the release of growth hormone and other hormones. Receptors: Somatostatin receptors (SSTRs) 1 through 5.

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Epinephrine

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Function: Also known as adrenaline, it enhances fight or flight response. Receptors: Alpha-1, alpha-2, beta-1, beta-2, and beta-3 adrenergic receptors.

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Endorphins

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Function: Reduce pain and induce feelings of pleasure. Receptors: Mu, delta, and kappa opioid receptors.

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Corticotropin-releasing hormone (CRH)

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Function: Stimulates secretion of adrenocorticotropic hormone (ACTH). Receptors: CRH receptors 1 and 2.

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Acetylcholine

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Function: Involved with muscle activation, attention, and arousal. Receptors: Nicotinic and muscarinic receptors.

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Nitric oxide

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Function: A retrograde neurotransmitter, modulating synaptic plasticity. Receptors: Soluble guanylate cyclase receptor.

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Anandamide

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Function: Plays a role in pain, appetite regulation, and mood. Receptors: CB1 and CB2 cannabinoids receptors.

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Oxytocin

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Function: Promotes bonding, social behavior and is involved in childbirth and lactation. Receptors: Oxytocin receptor.

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Glutamate

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Function: Major excitatory neurotransmitter in the central nervous system. Receptors: NMDA, AMPA, and kainate receptors.

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Substance P

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Function: Mediator of pain signals and inflammatory processes. Receptors: Neurokinin-1 (NK1) receptor.

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Brain-derived neurotrophic factor (BDNF)

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Function: Involved in neuron survival, growth, and differentiation. Receptors: TrkB receptor.

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Norepinephrine

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Function: Increases arousal and alertness, involved in fight or flight response. Receptors: alpha and beta adrenergic receptors.

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Glycine

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Function: Main inhibitory neurotransmitter in the spinal cord. Receptors: Glycine receptor.

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Adenosine

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Function: Generally inhibits neuronal activity and promotes sleep. Receptors: A1, A2A, A2B, and A3 receptors.

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Histamine

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Function: Involved in inflammatory response and regulation of stomach acid. Receptors: H1, H2, H3, and H4 receptors.

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Insulin

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Function: Regulates glucose uptake in the brain and affects satiety. Receptors: Insulin receptor.

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