Explore tens of thousands of sets crafted by our community.
Molecular Chaperones
15
Flashcards
0/15
Hsp70
Assists in protein folding and prevents aggregation; found across various cellular compartments such as the cytosol and endoplasmic reticulum.
Chaperonins
Provide an isolated environment for proper protein folding; an example is GroEL/GroES in bacteria.
Hsp90
Facilitates the stabilization and proper folding of proteins involved in signal transduction; present in the cytosol of eukaryotic cells.
Small Heat Shock Proteins (sHSPs)
Stabilize partially unfolded proteins, preventing aggregation; found in the cytoplasm and in organelles like mitochondria.
ER chaperones
Facilitate protein folding and quality control in the endoplasmic reticulum; BiP (Binding immunoglobulin Protein) is an example.
Cochaperones
Assist the main chaperones by modulating their activity and specificity; Hop (Hsp70-Hsp90 organizing protein) is an example.
Hsp60
Another term for chaperonins in eukaryotes and mitochondria, aiding in the correct folding of proteins translocated to the mitochondria.
DnaK/DnaJ/GrpE System
A prokaryotic molecular chaperone system that assists in protein folding, with DnaK as the Hsp70 homolog.
Hsp100/Clp Family
Works to disaggregate and reactivate aggregated proteins, often functioning in tandem with the Hsp70 system.
Calnexin/Calreticulin
Facilitate the folding of glycoproteins in the endoplasmic reticulum by binding to carbohydrate moieties.
T-complex Protein-1 Ring Complex (TRiC)
Chaperonin found in eukaryotes that assists in the folding of actin, tubulin, and other cytosolic proteins.
p97/Cdc48
ATPase associated with various cellular activities, involved in the extraction of misfolded proteins from the ER for degradation.
Prefoldin
Captures and stabilizes unfolded proteins, delivering them to a larger chaperonin for folding.
Sigma 32
Not a chaperone itself but a prokaryotic heat shock transcription factor that increases the synthesis of heat shock proteins, including chaperones.
Mitochondrial Import Stimulation Factor (MSF)
Enhances the import of proteins into mitochondria by interacting with mitochondrial chaperones.
© Hypatia.Tech. 2024 All rights reserved.